A woman should avoid conceiving for six months, after radioactive iodine treatment.A woman who had radioactive iodine to treat Graves' disease in the past should tell her doctor since your baby will need careful watch for thyroid-related problems which may occur in the later stages of pregnancy. Radioactive iodine therapy and antithyroid medications produce similar health-related quality-of-life outcomes in patients with Graves disease. DOI: 10.1001/jamaminternmed i had partial thyroidectomy after thyroid toxycosis 2003. got hyperthyroid again. We report a case of GD with the longest time-to-relapse so far published, i.e. Nsreen Ra Mohamadien Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Assiut University Egypt. A total of 1186 patients with Graves’ disease diagnosed between 2003 and 2005 in southern Sweden were included in the study. Thyroid-Related Patient-Reported Outcome questionnaire (ThyPRO): Change In Thyroid Nodule Volume Calculator, Find an Endocrinology – Thyroid Specialist, https://www.thyroid.org/radioactive-iodine/, Personalized Approach to Thyroid Disorders, Clinical Thyroidology for the Public (CTFP). In this long-term analysis, there were greater impairments of both thyroid-specific and general QoL scores in those who received RAI than in patients treated with ATD or surgery. Abraham-Nordling M, Torring O, Hamberger B, et al. After radioactive iodine treatment. After her original diagnosis of Graves’ disease, Williams decided on a single dose of radioactive iodine taken orally to destroy the misbehaving thyroid cells. Graves’ disease is usually treated with antithyroid drugs, radioactive iodine therapy, or surgery. However, in that study, there were high rates of relapse in those treated with an ATD (42% in the 20–34 age group and 34% in the 35–55 group) and more frequent eye problems in those treated with RAI. It's simple enough: 1. Among the three treatment groups, patients who received radioactive iodine therapy had worse thyroid-specific quality of life scores than patients treated with antithyroid drugs or surgery, as measured by ThyPRO. Graves’ disease is a common cause of hyperthyroidism and may be associated with a negative impact on patients’ quality of life (QoL) (1,2). Following treatment with radioactive iodine, the thyroid gland becomes smaller, the uptake of iodine by the gland is reduced, and the level of organic iodine in the plasma becomes normal. Limitations include differences in characteristics in the three groups, especially with regard to age and presence of comorbidities, and the lack of information on serum thyroid-function tests. The radioactive iodine therapy group had worse scores for goiter symptoms, hyperthyroid symptoms, tiredness, anxiety, depression, emotional susceptibility, impaired social life, impaired daily life, and impaired sex life than the antithyroid drug and surgery groups. Relapse of Graves' disease 23 years after treatment with radioactive iodine (131I) The use of radioactive iodine (131I) in the treatment of Graves' disease results frequently in hypothyroidism requiring thyroid hormone supplementation. Impaired quality of life after radioiodine therapy compared with antithyroid drugs or surgical treatment for Graves’ hyperthyroidism: a long-term follow-up with the Thyroid-Related Patient- Reported Outcome Questionnaire and 36-Item Short Form Health Status Survey. SUMMARY OF THE STUDY Overall, patients with treated Graves’ disease had worse thyroid-related quality of life scores than the general population. Tay WL(1), Lee LMY(1), Tong AKT(2), Chng CL(1). July 1, 2019. Patients treated with RAI had worse scores on all SF-36 scales than the ATD group, especially in the areas of general health, role limitations, and social function. Photo: 123rf . There are three main conventional treatment pathways for Graves disease: anti-thyroid drugs (ATDs), surgical removal of the thyroid (Thyroidectomy), and the destruction of the thyroid via radioactive iodine treatment … i had partial thyroidectomy after thyroid toxycosis 2003. got hyperthyroid again. However, patients treated with ATD or surgery had scores of tiredness and emotional susceptibility that were similar to those of the general population. Treatment of Graves’ Disease by the “Atomic Cocktail”by Malcolm R. Powell, M.D., F.A.C.P, F.A.C.N.PThe so-called “atomic cocktail” became available after World War II for the treatment of thyroid disease. In 2000, I underwent radioactive iodine ablation (RAI) for Grave’s disease. I pushed my doctors to do it because I was allergic to the anti-thyroid medications (they shut down my white cells) and I really wanted a normalized thyroid so I could get pregnant and not have to deal with the Grave’s disease anymore. Patients in surgery group were generally younger (average age 35 years, compared to 43 years for the antithyroid drug group and 54 years for the radioactive iodine therapy group). Properly treated hypothyroidism is seen as a much less serious problem than Graves. Patients were treated according to usual clinical practice. It is caused by antibodies that attack the thyroid and turn it on. Overall, patients with treated Graves’ disease had worse scores on thyroid-related QoL measures, as assessed by ThyPRO, than the general population. Patients who were treated with RAI were generally older and more likely to have had comorbidities than those treated with ATD or surgery. Radioiodine is the preferred therapy in the United States whereas in Europe and most of Asia, it is reserved as second line for patients who relapse after initial thionamide treatment [].The recent guidelines of the UK National Institute for Health and Care Excellence (NICE) recommends that radioiodine should now be first line treatment for Graves’ disease in the UK (Table 2) []. RAI-associated leakage of thyroid antigen(s) leads to an increased production of TSH These findings should be further substantiated in future studies, given the potential long-term implications of selecting treatment choices for patients with Graves’ disease. Robyn’s experience with RAI, Graves and a life forever impacted. So after 8 days half of the radiation contained in the original dose will have decayed away (been released), and after another 8 days the residual will be half again. Quality of Life Is Worse at 6-10 Years after Radioactive Iodine Treatment of Graves’ Disease as Compared with Antithyroid Drugs or Surgery Sun Y. Lee 9 … Radioactive Iodine treatment for Graves’ disease – what you should know. Today radioactive iodine is in common use to suppress the hyperthyroidism that accompanies Graves’ disease. Graves disease, the most common form of hyperthyroidism, occurs most often in women, is treated with radioactive iodine, given as a pill. Afterward, she was allowed to go home but had to steer clear of other people–including her husband—for 48 hours to … Graves’ disease is a toxic form of hyperthyroidism that may require immediate treatment. Author information: (1)Department of Endocrinology, Singapore General Hospital, Singapore Quality of Life Is Worse at 6-10 Years after Radioactive Iodine Treatment of Graves’ Disease as Compared with Antithyroid Drugs or Surgery Sun Y. Lee Sun Y. Lee Section of Endocrinology, Diabetes, and Nutrition; Department of Medicine, Boston University School of Medicine, Boston Medical Center, Boston, Massachusetts, U.S.A. Lower scores in ThyPRO represent better health status. Graves’ disease is a common cause of an overactive thyroid gland (hyperthyroidism). THE FULL ARTICLE TITLE: Thyroid 29:322–331. Sleep apart from adults by at least six feet (a separate bedroom is recommended) and avoid sexual activity. Long-term if radioactive iodine treatment or surgery is contraindicated or declined. Impaired health-related quality of life in Graves’ disease: a prospective study, Quality of life in patients with benign thyroid disorders: a review, Quality of life aspects and costs in treatment of Graves’ hyperthyroidism with antithyroid drugs, surgery, or radioiodine: results from a prospective, randomized study, Graves’ disease: a long-term quality-of-life follow up of patients randomized to treatment with antithyroid drugs, radioiodine, or surgery, Impaired quality of life after radioiodine therapy compared with antithyroid drugs or surgical treatment for Graves’ hyperthyroidism: a long-term follow-up with the Thyroid-Related Patient-Reported Outcome Questionnaire and 36-Item Short Form Health Status Survey, Thyroid-associated ophthalmopathy: quality of life follow-up of patients randomized to treatment with antithyroid drugs or radioiodine, https://doi.org/10.1089/ct.2019;31.144-147, http://doi.org/10.1089/ct.2019;31.144-147. You usually need to take levothyroxine for life after radioactive iodine treatment (RAI) if you have Graves’ disease but not for as long if the cause of the thyroid over-activity is a toxic multinodular goitre or … All rights reserved, USA and worldwide. Thyroid 29:322–331. Afterward, she was allowed to go home but had to steer clear of other HYPERTHYROIDISM Association of radioactive iodine treatment with cancer mortality in patients with hyperthyroidism. In this study, quality of life scores were worse in patients with Graves’ disease treated with radioactive iodine therapy compared to antithyroid drugs or surgery at 6-10 years after treatment. Although age and presence of comorbidities were adjusted for the analyses, there may have been some selection bias for RAI treatment, such as a contraindication for surgery and suboptimal treatment response to or recurrence with an ATD alone. Severe radiation thyroiditis after radioactive iodine for treatment of Graves’ disease. Flush Twice: Life After Radioactive Iodine Treatment I didn't know what to expect when I received the treatment last Friday. Relapse of Graves' disease months after … Your doctor examines your eyes to see if they're irritated or protruding and looks to see if your thyroid gland is enlarged. Enter your email address below and we will send you the reset instructions. Only those in whom thyroid ophthalmopathy developed had worse QoL, which was more frequent in the RAI-treated group than in the ATD-treated group (46% and 27.6%, respectively). Törring O et al 2019. Age, sex, and presence of comorbidities (presence of diabetes type 1 or 2, vitamin B12 deficiency, rheumatic disease, celiac disease, Addison's disease, vitiligo, psoriasis, sarcoidosis, and other chronic disease) were assessed to adjust for potential confounders. Studies have shown that having Graves’ disease may have negative impact on patient’s quality of life. Radioactive Iodine (RAI), I 131 is one of the treatments for Graves’ disease and thyroid cancer. Patients were assessed at an average of 8 years after the diagnosis of Graves’ disease. Find out what happens after having radioactive iodine treatment. Graves’ disease is usually treated with antithyroid drugs, radioactive iodine … Higher scores on SF-36 represent better health status. Thyroid carcinoma after radioactive iodine therapy for Graves' disease. This means avoiding public transportation, hotels, carpools, and in some cases, your workplace. PMID: 30667296. The current study was conducted to assess long-term QoL in patients with Graves’ disease who have been treated in a routine clinical setting. In acute thyroiditis, in spite of a high basal metabolic rate, high content of organic iodine in the plasma and other evidences of “hyperthyroidism,” the uptake of I 131 has been very low. What is radioactive iodine treatment? An association between radioactive iodine (RAI) therapy for GD and the development or worsening of Graves' orbitopathy (GO) is widely quoted. I-131 is the destructive form used to destroy thyroid tissue in the treatment of thyroid cancer and with an overactive thyroid. Iodine is normally concentrated by the thyroid gland and is used to make Patients were divided into three groups: (i) 347 patients treated with antithyroid drugs only, (ii) 395 patients treated with radioactive iodine therapy (with or without previous treatment with antithyroid drugs), but not surgery, and (iii) 233 patients treated with surgery to remove thyroid gland (with or without previous treatment with antithyroid drugs or radioactive iodine therapy). Is such a drastic treatment justifiable for Graves’ disease? Hyperthyroidism may be treated with antithyroid meds (Methimazole, Propylthiouracil), radioactive iodine or surgery. Patients treated with RAI had worse scores than those who underwent surgery except in bodily pain and in the physical component summary. QoL was assessed using the validated Swedish versions of the Thyroid-Related Patient-Reported Outcome Questionnaire (ThyPRO; n = 975) and the general 36-Item Short Form Health Status Survey (SF-36; n = 964) questionnaires completed by participants; scores from ThyPRO were compared with scores from a general population sample (n = 712). Radioactive iodine is very effective, is safe and rarely causes side-effects. Those with recurrent Graves’ disease were excluded. BACKGROUND Thyroid-Related Patient-Reported Outcome questionnaire (ThyPRO): a validated questionnaire in determining quality of life in patients with thyroid disorders, A publication of the American Thyroid Association. Effectiveness of radioactive iodine (131I) in the treatment of Graves' disease: single center experience in Assiut University hospital. It is best to discuss all your doubts with your doctor before taking any decision. Radioactive Iodine (RAI), I 131 is one of the treatments for Graves’ disease and thyroid cancer. treatment was started They found a nodule and had it biopsied. Abstract Background: Relapse of Graves’ disease (GD) after a prolonged period of radioactive iodine (RAI)-induced hypothyroidism is very unusual. Radioactive Iodine Treatment (RAI) is one of the most popular (and world wide recommended treatments) for Graves’ Disease and Hyperthyroidism. this time went for radioactive iodine treatment. ... Hi all. Graves’ disease: the most common cause of hyperthyroidism in the United States. It is a very effective treatment for thyroid cancer but what about Graves’ disease. I had radioactive iodine therapy for my Graves Disease two weeks ago. In addition, the RAI group had worse scores in hypothyroid symptoms, eye symptoms, and appearance than the ATD group. Previous studies have reported similar general-health QoL with the three treatment methods, but were limited to shorter-term follow up (3,4). Some Graves’ patients have achieved remission after years of therapy using anti-thyroid drugs combined with levothyroxine (modified block and replace therapy). After 18 months of antithyroid therapy, similar monitoring is indicated to detect relapse or changes in thyroid function. No Excess Cancer Risk from Radioactive Iodine Treatment in Radioactive iodine therapy … Copyright 2019 American Thyroid Association, Inc. © 2021 Mary Ann Liebert, Inc., publishers. This study had a larger number of participants and a longer duration of follow up than previous studies. 32 years after therapy with RAI. Median ages were significantly different for the treatment groups: 43 years (range, 33–55) for the ATD group, 54 years (range, 45–63) for the RAI group, and 35 years (range, 29–46) for the surgery group. This is different from previous studies of quality of life in patients treated for Graves’ disease which showed similar quality of life in patients treated with three treatment methods. For a few days after radioactive iodine treatment, you will be slightly radioactive. . Participants were divided in three groups: (i) patients treated with ATDs only, (ii) patients treated with RAI (with or without previous treatment with ATD), but not surgery, and (iii) patients treated with subtotal or total thyroidectomy (with or without previous treatment with ATD or RAI). The purpose of this retrospective study was to clarify the possible risk factors of early hypothyroidism after RAI therapy in Graves’ disease. In August I was diagnosed with Graves Disease- I had all the scans done along with radioactive iodine uptake which pointed to Graves disease.Right before Radioactive Iodine treatment was started They found a nodule and had it biopsied. If these findings are confirmed in other studies in other countries, it would suggest that radioactive iodine therapy may be less desirable in the long term as compared to antithyroid drugs or surgery, Graves’ Disease: https://www.thyroid.org/graves-disease/, Hyperthyroidism (Overactive): https://www.thyroid.org/hyperthyroidism/, Radioactive Iodine: https://www.thyroid.org/radioactive-iodine/, Thyroid Surgery: https://www.thyroid.org/thyroid-surgery/. We report a case of GD with the longest time-to-relapse so far published, i.e. Quality of life was assessed using two different questionnaires at an average of 8 years after the diagnosis of Graves’ disease. We immediately moved forward to discussing treatment options, and the doctor was quite pushy in his recommendation of radioactive iodine. More patients in radioactive iodine therapy group had other medical conditions that may affect quality of life (44%, compared to 29% in the antithyroid drug group and 33% in the surgery group). An association between radioactive iodine (RAI) therapy for GD and the development or worsening of Graves' orbitopathy (GO) is widely quoted. You usually need to take levothyroxine for life after radioactive iodine treatment (RAI) if you have Graves’ disease but not for as long if the cause of the thyroid over-activity is a toxic multinodular goitre or a solitary toxic thyroid Radioactive iodine uses a form of iodine that is radioactive. From this cohort, 1186 patients with Graves’ disease were recruited for the current study 6 to 10 years after the original diagnosis to assess QoL measures. JAMA Internal Medicine. A woman should avoid conceiving for six months, after radioactive iodine treatment.A woman who had radioactive iodine to treat Graves' disease in the past should tell her doctor since your baby will need careful watch for thyroid-related problems which may occur in the later stages of pregnancy. Is such a drastic treatment justifiable for Graves’ disease? What is radioactive iodine treatment? The dose of radiation used during radioactive iodine treatment is very low, but there are some precautions you'll need to take after treatment: avoid prolonged close contact with children and pregnant women for a few days or weeks women should avoid getting pregnant for at least 6 months men should not father a child for at least 4 months Background: Relapse of Graves’ disease (GD) after a prolonged period of radioactive iodine (RAI)-induced hypothyroidism is very unusual. So what she really want any of the other 5 massage can increase your immune system. Regardless of treatment method, patients with Graves’ disease had worse QoL measures at 6 to 10 years after diagnosis than the general population. I pushed my doctors to do it because I was allergic to the anti-thyroid medications (they shut down my white cells) and I really wanted a normalized thyroid so I could get pregnant and not have to deal with the Grave’s disease anymore. i have graves disease. After having treatment. Patients who choose radioactive iodine therapy to treat hyperthyroidism and Graves disease are not at increased risk for developing cancer, say experts. Treatment of Graves’ Disease by the “Atomic Cocktail”by Malcolm R. Powell, M.D., F.A.C.P, F.A.C.N.PThe so-called “atomic cocktail” became available after World War II for the treatment of thyroid disease. Radioactive Iodine (RAI), I 131 is one of the treatments for Graves’ disease and thyroid cancer. People with severe hyperthyroidism, a large goitre, or recent exposure to iodide may need a longer duration of treatment. Graves’ disease is typically treated with anti-thyroid medication, radioactive iodine therapy, or surgery. this time went for radioactive iodine treatment. 2. ? Findings from a study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer. Additionally, another randomized study of 308 patients showed no difference in general QoL measures, as assessed by SF-36, after ATD or RAI treatment at 4-year follow-up (6). Author Sun Y. Lee Subject Clinical Thyroidology for the Public Volume 12 Issue 4 Previous studies have reported that general-health quality of life among patients treated with three treatment methods as similar, but they were limited by a smaller number of participants or a shorter duration of follow up. A similar pattern was found in general quality of life measures as assessed with the SF-36 questionnaire, with worse scores in radioactive iodine therapy group compared to the antithyroid drug or surgery groups. These patients may have had a more prolonged or complicated disease course, which could have contributed to worse QoL measures. After her original diagnosis of Graves’ disease, Williams decided on a single dose of radioactive iodine taken orally to destroy the misbehaving thyroid cells. Graves’ disease is a common cause of an overactive thyroid gland (hyperthyroidism). Today radioactive i have graves disease. life after radioactive iodine yan_res Hi, I'm a 29 y/o male. 32 years after therapy with RAI. Among the three treatment groups, patients who received radioactive iodine treatment had worse thyroid-specific quality of life scores than patients treated with antithyroid drugs or surgery. 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